SOMGRAM 40 Tablet

SOMGRAM 40

Esomeprazole 40 mg Gastro-Resistant Tablets

Product Overview

SOMGRAM 40 contains Esomeprazole 40 mg, a proton pump inhibitor (PPI) used to reduce excessive gastric acid production. It is indicated in the management of acid-related gastrointestinal conditions, including gastroesophageal reflux disease (GERD), erosive esophagitis, and certain conditions associated with excessive gastric acid secretion.

The gastro-resistant formulation is designed to protect the active ingredient from degradation by stomach acid, allowing esomeprazole to reach the site where it is absorbed.

Composition

Each gastro-resistant tablet contains:

• Esomeprazole Magnesium IP
  Equivalent to Esomeprazole 40 mg
• Excipients: q.s.
• Colour: Red Oxide of Iron

What is Esomeprazole?

Esomeprazole is the S-isomer of omeprazole and belongs to the proton pump inhibitor (PPI) class of medicines. It works by selectively inhibiting the H⁺/K⁺-ATPase proton pump in gastric parietal cells, thereby reducing the final step of gastric acid secretion.

By decreasing gastric acid production, esomeprazole helps relieve acid-related symptoms and supports healing of acid-induced damage to the oesophagus and other gastrointestinal tissues.

Mechanism of Action

Esomeprazole suppresses gastric acid secretion by inhibiting the proton pump located in the secretory canaliculi of gastric parietal cells.

It binds to the proton pump after activation in the acidic environment of the parietal cell and inhibits the secretion of hydrogen ions into the stomach. This results in a substantial reduction in both basal and stimulated gastric acid secretion.

The reduction in gastric acidity helps provide symptomatic relief and promotes healing in acid-related gastrointestinal disorders.

Therapeutic Indications

SOMGRAM 40 may be prescribed for the management of:

• Gastroesophageal reflux disease (GERD)
• Healing and maintenance treatment of erosive esophagitis
• Symptomatic GERD and acid-related symptoms
• Peptic ulcer disease, as part of an appropriate treatment regimen
• Helicobacter pylori-associated ulcer disease, in combination with suitable antibiotics and other medicines as prescribed
• Prevention and treatment of NSAID-associated gastric and duodenal ulcers in appropriate patients
• Hypersecretory conditions, such as Zollinger–Ellison syndrome, under specialist supervision

The appropriate indication, dosage and duration depend on the patient's clinical condition and should be determined by a healthcare professional.

Benefits of SOMGRAM 40

SOMGRAM 40 provides potent suppression of gastric acid secretion and may help:

• Reduce heartburn and acid-related discomfort
• Control symptoms associated with acid reflux
• Promote healing of acid-damaged oesophageal tissue
• Support healing of acid-related gastrointestinal ulcers
• Reduce recurrence of acid-related symptoms when used as maintenance therapy where clinically appropriate
• Provide sustained acid suppression with once-daily dosing in many approved indications

Dosage and Administration

Dosage: As directed by the physician.

The dose and duration of treatment depend on the indication, severity of symptoms, age, medical history and response to therapy.

SOMGRAM 40 should generally be taken before meals, according to the prescribing instructions.

The tablet should be swallowed whole with water. It should not be chewed or crushed, as it is a gastro-resistant formulation.

Patients should follow the prescribed dose and should not alter the treatment regimen without consulting their healthcare professional.

How to Take SOMGRAM 40

For best results:

1. Take the tablet exactly as prescribed.
2. Preferably take it before a meal when instructed by the physician.
3. Swallow the tablet whole with water.
4. Do not crush, chew or break the gastro-resistant tablet.
5. Take the medicine at approximately the same time each day if prescribed regularly.
6. Complete the prescribed course, particularly when it is being used as part of combination treatment for H. pylori infection.

Possible Side Effects

Like other medicines, esomeprazole may cause side effects in some patients.

Commonly reported adverse effects may include:

• Headache
• Abdominal pain
• Diarrhoea
• Constipation
• Flatulence
• Nausea or vomiting

Most adverse effects are generally mild and transient. However, patients should consult their healthcare professional if symptoms are persistent, severe or concerning.

Long-term PPI therapy may be associated with certain risks in susceptible individuals, including vitamin B12 deficiency, hypomagnesaemia, certain gastrointestinal infections and bone fractures. Long-term treatment should therefore be used at the appropriate dose and duration under medical supervision.

Precautions and Warnings

Before taking SOMGRAM 40, inform the healthcare professional if you:

• Have a history of allergy to esomeprazole, other proton pump inhibitors or any component of the formulation
• Have significant liver disease
• Are taking medicines regularly, including prescription, OTC or herbal products
• Have unexplained weight loss, recurrent vomiting, difficulty or pain while swallowing, gastrointestinal bleeding or persistent symptoms
• Require long-term acid-suppressive therapy

Persistent or new gastrointestinal symptoms should be appropriately evaluated rather than being treated solely with acid suppression.

Drug Interactions

Esomeprazole may interact with certain medicines. Tell your healthcare professional about all medicines you are taking.

Particular attention may be required with medicines such as:

• Clopidogrel
• Warfarin and other anticoagulants
• Diazepam
• Phenytoin
• Certain antiretroviral medicines
• Methotrexate at high doses
• Tacrolimus
• Digoxin
• Medicines whose absorption depends on gastric acidity

The clinical significance of an interaction depends on the medicine and the patient's individual circumstances. A healthcare professional should review concomitant medications when appropriate.

Use in Pregnancy and Lactation

If you are pregnant, planning pregnancy or breastfeeding, consult your doctor before using SOMGRAM 40.

The medicine should be used during pregnancy or lactation only when considered appropriate by the treating healthcare professional.

Use in Special Populations

Elderly:
Dose adjustment is generally not required solely on the basis of age, although treatment should be individualized.

Patients with liver impairment:
Dose selection may require consideration of the severity of hepatic impairment. Patients with significant liver disease should use esomeprazole under medical supervision.

Patients with kidney impairment:
Routine dose adjustment is generally not required, but treatment should be used according to the prescribing information and clinical circumstances.

Storage

• Store in a cool, dry and dark place.
• Protect from light.
• Keep the medicine in its original packaging until use.
• Keep out of reach of children.
• Do not use the medicine after the expiry date printed on the pack.
• Do not use tablets if the packaging is damaged or the product shows any unusual change in appearance.

Frequently Asked Questions

What is SOMGRAM 40 used for?

SOMGRAM 40 contains esomeprazole 40 mg and is used to reduce gastric acid production in conditions such as GERD, erosive esophagitis and other acid-related gastrointestinal disorders.

Is SOMGRAM 40 an antacid?

No. SOMGRAM 40 is a proton pump inhibitor (PPI). Unlike conventional antacids, it reduces the production of gastric acid by inhibiting the gastric proton pump.

Can SOMGRAM 40 be crushed?

No. The tablet is gastro-resistant and should be swallowed whole. Do not chew or crush it.

When should SOMGRAM 40 be taken?

The timing depends on the prescribed indication. It is commonly taken before meals. Follow the specific instructions provided by your doctor.

Can SOMGRAM 40 be used for acidity and heartburn?

Esomeprazole is commonly used for acid-related symptoms such as heartburn and acid reflux. However, persistent or recurrent symptoms should be evaluated by a healthcare professional.

Can SOMGRAM 40 be used for H. pylori infection?

Esomeprazole may be used as part of a combination eradication regimen containing appropriate antibiotics and other medicines. It should not be used alone to eradicate H. pylori.

Important Information

SOMGRAM 40 is a prescription medicine and should be used under the guidance of a qualified healthcare professional. The information provided on this website is intended for general educational and informational purposes and should not replace professional medical advice, diagnosis or treatment.

Composition: Esomeprazole Magnesium IP equivalent to Esomeprazole 40 mg
Dosage Form: Gastro-resistant tablet
Therapeutic Category: Proton Pump Inhibitor (PPI)
Route of Administration: Oral
Dosage: As directed by the physician.

Disclaimer: The information provided on this website by Ingram Biosciences Private Limited is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. All medicines should be used strictly as per the advice of a qualified healthcare professional and applicable prescribing information. Product information is subject to change in accordance with applicable regulatory requirements. The Company endeavours to ensure accuracy but does not warrant that all information is complete or error-free. To the extent permitted by applicable law, the Company shall not be liable for any loss arising from misuse or unauthorised reliance on website information. Nothing in this disclaimer excludes any liability or rights that cannot legally be excluded or limited under applicable Indian law. For medical advice or product-related concerns, please consult a qualified healthcare professional or contact the Company through its official channels.